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KMID : 1007020030010020130
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Korean Soceity of Osteroporosis
2003 Volume.1 No. 2 p.130 ~ p.139
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The Calcitonin Gene (CA) Polymorphism, Bone Mineral Density, and Bone Responsivenesss to Hormone Treatment in Postmenopausal Korean Women
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Kim Jung-Gu
Ku Seung-Yup
Jee Byung-Chul
Suh Chang-Suk
Kim Seok-Hyun
Choi Young-Min
Moon Shin-Yong
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Abstract
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Objectives: To evaluate the relationship between cytosine-adenine (CA) polymorphism of the calcitonin gene, serum calcitonin levels, bone mineral density (BMD) and bone responsiveness to hormone replacement therapy (HRT).
Methods: The calcitonin gene (CA) polymorphism was analyzed by genescan and DNA sequencing in 430 postmenopausal Korean women. Serum calcitonin, osteocalcin (OST), bone alkaline phosphatase (BAP), and CrossLaps (CTX) were measured by immunoassay, and enzyme linked immunosorbent assay respectively. BMD at the lumbar spine and proximal femur was determined by dual energy X-ray absorptiometry. In all, 181 women were treated with sequential HRT for 2 years.
Results: Four major calcitonin alleles were present with a frequency greater than 5 %: 122 bp 61.3 %, 108 bp 25.1 %, 110 bp 7.0 %, and 124 bp 6.2 %. There were no differences in the BMD at the lumbar spine and proximal femur in postmenopausal women with zero, one, or two copies of major alleles. Serum calcitonin levels in women with two copies of the 108 bp allele were significantly higher than those in women with zero or one copy of the 108 bp allele. The annual rate of change of BMD at the femoral neck after HRT was significantly higher in women homozygous for the 108 bp allele than in women with zero or one copy of the 108 bp allele, but the number of copies of the major calcitonin alleles was not significantly associated with HRT-responsiveness. After HRT of 6 months, serum calcitonin levels decreased significantly in women carrying at least one 108 bp allele than in women who did not carry this allele, while no significant differences in the change rate in bone turnover markers were noted.
Conclusions: The calcitonin (CA) polymorphism is one of genetic factors that may affect BMD changes at the femoral neck after HRT in Korean women.
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KEYWORD
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Bone Mineral Density, Calcitonin, Polymorphism, HRT
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